Trey Faltine and Mike Antico each led off innings with home runs, but the Longhorns were limited to five hits in the loss.
Texas Tech (29-10, 9-7) started the scoring with a solo home run to lead off the second.
Texas (34-10, 12-4) took the lead with a pair of runs in the third inning. Faltine led off the inning with a line-drive home run to left field to even the score, 1-1. Mitchell Daly then drew a one-out walk and would come around to score on an RBI groundout by Cam Williams to put Texas up 2-1.
The Red Raiders regained the lead with a pair of runs in the fourth and added three more in the fifth to make it a 6-2 ballgame.
Antico got one back for the Longhorns in the fifth with a solo home run to lead off the inning, cutting the Texas Tech advantage to 6-3.
Drew Shifflet struck out four batters in two scoreless innings of work out of the bullpen. Coy Cobb pitched a scoreless eighth and Palmer Wenzel threw a 1-2-3 ninth.
The Longhorns and Red Raiders will square off in game two on Saturday at 12:00 p.m. at UFCU Disch-Falk Field.